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Antigenic Specificity | PUMA (NT) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, Rainbow trout |
Isotype | n/a |
Format | APC-Cy7 conjugate |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects the N-terminal domain of PUMA ~23 kDa. Detects ~16 kDa bands sometimes, possibly corresponding to PUMAbeta. Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 up-regulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta (1). PUMA proteins bind Bcl-2, localize to the mitochondri |
Immunogen | Immunogen: N-terminal amino acids of human PUMA |
Other Names | [Rabbit Human PUMA (NT); BBC3; BCL2 binding component 3; p53 up regulated modulator of apoptosis; PUMA/JFY1] |
Gene, Accession # | [PUMA], Gene ID: 6774, NCBI: AAK17196.1, UniProt: Q9BXH2 |
Catalog # | MBS8004247 |
Price | $510 |
Order / More Info | PUMA (NT) Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Nakano K., Vousden K.H. (2001) Mol Cell. 2001; 7(3): 683-94. 2. Yu J., Zhang L., Hwang P.M., Kinzler K.W., Vogelstein B. (2001) Mol Cell. 7(3): 673-82. 3. Han J., et al. (2001) Proc Natl Acad Sci U S A. 98(20): 11318-23. |