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Antigenic Specificity | UBE2A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human UBE2A (NP 003327.2). |
Other Names | [UBC2; HHR6A; MRXSN; RAD6A; MRXS30] |
Gene, Accession # | [UBE2A], Gene ID: 7319, NCBI: P49459.2, UniProt: P49459 |
Catalog # | MBS8548701 |
Price | $280 |
Order / More Info | UBE2A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |