Edit |   |
---|---|
Antigenic Specificity | Phospho-AKT1 (Tyr474) polyconal |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB); Immunoblot; ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal antibody to detect AKT1 (Phospho-Tyr474) in human samples. The serine/threonine kinase Akt family contains several members; including Akt1 (also designated PKB or RacPK); Akt2 and Akt 3; which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. They have a pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-? tyrosine residues 740 and 751; which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level |
Immunogen | Immunogen: Synthetic peptide |
Other Names | [PKB; c-Akt; RAC], [AKT1; AKT1; AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA; PKB; RAC; PKB; PKB alpha] |
Gene, Accession # | [AKT1], Gene ID: 207, NCBI: NP_001014431.1, UniProt: P31749 |
Catalog # | MBS845914 |
Price | $345 |
Order / More Info | Phospho-AKT1 (Tyr474) polyconal Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |