DIS3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DIS3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: DIS3 antibody detects endogenous levels of DIS3. Function: Putative catalytic component of the RNA exosome complex which has 3'-> 5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic h |
| Immunogen | Immunogen: A synthesized peptide derived from human DIS3. Subcellular Location: Cytoplasm. Nucleus > Nucleolus. Nucleus > Nucleoplasm. Nucleus. Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3. Tissue Specificity: Widely expressed. Predicted Cross Reactivity: Pig, Zebrafish, Horse, Sheep, Rabbi |
| Other Names | [2810028N01Rik; bA555G22; Dis3; DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog (S. cerevisiae); DIS3 mitotic control homolog; DIS3 mitotic control, S. cerevisiae, homolog of; dis3p; EXOSC11; Exosome complex exonuclease RRP44; exosome component 11; KIAA1008; Mitotic control protein dis3 homolog; Protein DIS3 homolog; Ribosomal RNA processing protein 44; Ribosomal RNA processing protein 44, S. cerevisiae, homolog of; Ribosomal RNA-processing protein 44; RP11-342J4.3; RRP44; RRP44_HUMAN] |
| Gene, Accession # | [DIS3], Gene ID: 22894, NCBI: NP_001121698.1, UniProt: Q9Y2L1 |
| Catalog # | MBS9603611 |
| Price | $240, $280 |
| Order / More Info | DIS3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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