PHLDA3 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPHLDA3
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatimmunogen affinity purified
Size0.05 mL, 0.1 mL
Concentration1.0 mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionThe antibody detects endogenous levels of total PHLDA3 protein. p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.Frank D., Mamm. Genome 10:1150-1159(1999).Ota T., Nat. Genet. 36:40-45(2004).The MGC Project Team, Genome Res. 14:2121-2127(2004).
ImmunogenImmunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human PHLDA3.
Other Names[Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; PHLDA3; TIH1]
Gene, Accession #[PHLDA3], Gene ID: 23612, NCBI: NP_036528.1, UniProt: Q9Y5J5
Catalog #MBS9400903
Price$200, $255
Order / More InfoPHLDA3 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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