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Antigenic Specificity | PHLDA3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total PHLDA3 protein. p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.Frank D., Mamm. Genome 10:1150-1159(1999).Ota T., Nat. Genet. 36:40-45(2004).The MGC Project Team, Genome Res. 14:2121-2127(2004). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human PHLDA3. |
Other Names | [Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; PHLDA3; TIH1] |
Gene, Accession # | [PHLDA3], Gene ID: 23612, NCBI: NP_036528.1, UniProt: Q9Y5J5 |
Catalog # | MBS9400903 |
Price | $200, $255 |
Order / More Info | PHLDA3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |