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Antigenic Specificity | Advanced glycosylation end product-specific receptor |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | caprylic acid ammonium sulfate precipitate |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total Advanced glycosylation end product-specific receptor polyclonal antibody. Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, |
Immunogen | Immunogen: Recombinant Human Advanced glycosylation end product-specific receptor protein |
Other Names | [Receptor for advanced glycosylation end products; AGER; RAGE] |
Gene, Accession # | Gene ID: 177, NCBI: NP_001127.1, UniProt: Q15109 |
Catalog # | MBS9415259 |
Price | $320 |
Order / More Info | Advanced glycosylation end product-specific receptor Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |