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Antigenic Specificity | PTPRC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein phosphatase (PTP) receptor CD45 is a type I transmembrane protein comprised of a pair of intracellular tyrosine phosphatase domains and a variable extracellular domain generated by alternative splicing (1). The catalytic activity of CD45 is a function of the first phosphatase domain (D1) while the second phosphatase domain (D2) may interact with and stabilize the first domain, or recruit/bind substrates (2, 3). CD45 interacts directly with antigen receptor complex proteins or activates Src family kinases involved in the regulation of T- and B-cell antigen receptor signaling (1). Specifically, CD45 dephosphorylates Src-family kinases Lck and Fyn at their conserved negative regulatory carboxy-terminal tyrosine residues and upregul |
Immunogen | Immunogen: A synthetic peptide of human PTPRC Observed Molecular Weight: 147kDa |
Other Names | [B220; CD45; CD45R; GP180; LCA; LY5; T200] |
Gene, Accession # | [PTPRC], Gene ID: 5788, NCBI: AAH14239.1 |
Catalog # | MBS2527897 |
Price | $150, $225, $360 |
Order / More Info | PTPRC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |