Edit |   |
---|---|
Antigenic Specificity | Human CD220 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mg |
Concentration | IgG concentration 0.1mg/ml |
Applications | Immunohistology Paraffin* |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This item detects an epitope within in the internal domain of human CD220, also known as Insulin receptor (INRS). CD220 is a heterotetrameric membrane glycoprotein consisting of four disulfide linked subunits; two alpha subunits and two beta subunits. CD220 is a member of the tyrosine kinase family of receptors, and mediates the effects of insulin and IGF-I (insulin-like growth factor-I) through the activation of insulin receptor substrate (IRS) proteins and downstream effector cascades. . . Activation of CD220 leads to a number of cellular effects, including glucose uptake, the regulation of cell proliferation and gene expression. These effects mostly occur in skeletal muscle, fat and the liver. Neuronal CD220 signalling has been shown t |
Immunogen | Immunogen: Synthetic peptide corresponding to human CD220 - conjugated to KLH. Histology Positive Control Tissue: Pancreas, Islet of Langerhans Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antisera to CD220 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human |
Other Names | [insulin receptor isoform Long preproprotein; Insulin receptor; insulin receptor; IR; insulin receptor; CD_antigen: CD220Cleaved into the following 2 chains:Insulin receptor subunit alpha; Insulin receptor subunit beta], [INSR; INSR; HHF5; CD220; IR] |
Gene, Accession # | [CD220], Gene ID: 3643, NCBI: NP_000199.2, UniProt: P06213 |
Catalog # | MBS221504 |
Price | $550 |
Order / More Info | Human CD220 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |