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Antigenic Specificity | LYN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells (1). Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivalent to Tyr416 of Src), located in the catalytic domain, correlates with enzyme activation. Csk-mediated phosphorylation of the carboxy-terminal Tyr507 (equivalent to Tyr527 of Src) inactivates the kinase. Tyrosine phosphorylation and activation of Lyn occurs upon association with cell surface receptors such as the B cell Ag receptor (BCR) and CD40 (2-4). Studies using knockout mice have shown that the net effect of Lyn deficiency is to render B cells hypersensitive to BCR stimulation (5- |
Immunogen | Immunogen: Recombinant protein of human LYN Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [FLJ26625; JTK8] |
Gene, Accession # | [LYN], Gene ID: 4067, NCBI: NP_001104567.1, UniProt: P07948 |
Catalog # | MBS8502512 |
Price | $310 |
Order / More Info | LYN Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Yamanashi, Y. et al. (1989) Proc. Natl. Acad. Sci. USA 86, 6538-6542. 2. Yamanashi, Y. et al. (1991) Science 251, 192-194. 3. Burkhardt, A.L. et al. (1991) Proc. Natl. Acad. Sci. USA 88, 7410-7414. 4. Ren, C.L. et al. (1994) J. Exp. Med. 179, 673-680. 5. Wang, J. et al. (1996) J. Exp. Med. 184, 831-838. 6. Chan, V.W. et al. (1997) Immunity 7, 69-81. 7. Hibbs, M. L. et al. (1995) Cell 83, 301-311. 8. Seo, S.J. et al. (2001) J. Immunol. 166, 3710-3723. |