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Antigenic Specificity | MLK1/2 (Phospho-Thr312/266) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of MLK1/2 only when phosphorylated at threonine 312/266. The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.Durkin J.T., Biochemistry 43:16348-16355(2004).The MGC Project Team; Genome Res. 14:2121-2127(2004).Dorow D.S.,Nature 446:153-158(2007). |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of threonine 312/266(A-G-T(p)-Y-A) derived from Human MLK1/2. |
Other Names | [M3K9; PRKE1; mixed-lineage protein kinase 1] |
Gene, Accession # | [MLK1/2], Gene ID: 4293, NCBI: NP_001271159.1, UniProt: P80192 |
Catalog # | MBS9414936 |
Price | $200, $255 |
Order / More Info | MLK1/2 (Phospho-Thr312/266) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |