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Antigenic Specificity | PTPN22 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total PTPN22 protein. Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.Cohen S., Blood 93:2013-2024(1999).Liu T., Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.Wang S., Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from Internal of human PTPN22. |
Other Names | [Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; LYP1] |
Gene, Accession # | [PTPN22], Gene ID: 26191, NCBI: NP_001180360.1, UniProt: Q9Y2R2 |
Catalog # | MBS9403281 |
Price | $200, $255 |
Order / More Info | PTPN22 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |