Glycogen Synthase Kinase-3 beta Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Glycogen Synthase Kinase-3 beta |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, rat, mouse |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody detects a 46 kDa* protein corresponding to the apparent molecular mass of GSK-3 beta on SDS-PAGE immunoblots of rabbit fibroblasts, mouse brain, as well as human SKN-SH and A431 cells. Glycogen synthase kinase-3 (GSK-3) has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control, and oncogenesis. Two GSK-3 genes (alpha and beta) have been cloned in mammals and these kinase homologues show strong sequence conservation within their catalytic domain. GSK-3beta plays a critical role in cell survival by phosphorylating nuclear factor-kappa-B (NF- kappa-B) p65 subunit, leading to NF-kappa-B transactivation in hepatocytes. Phosphorylation regulates the activity of both GSK-3 |
| Immunogen | Immunogen: Clone M131 was generated from a recombinant protein containing amino acid residues in the N-terminal region of human GSK-3 beta. This sequence is highly conserved in rat and mouse GSK-3 beta, but has low homology to GSK-3 alpha. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS470016 |
| Price | $325 |
| Order / More Info | Glycogen Synthase Kinase-3 beta Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Hagen, T. et al. (2002) J Biol Chem. 277(26):23330.• Takahashi-Yanaga, F. et al. (2004) Biochem Biophys Res Commun. 316(2):411.• Xinbo, L. et al. (2003) Mol Cancer Ther. 2:1215. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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