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Antigenic Specificity | Phospho-GSK3B (Ser9) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | humanpredicted: mouse, rat, Xenopus |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This Phospho-GSK3B (Ser9) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-33 amino acids from human GSK3B. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the |
Immunogen | n/a |
Other Names | [Glycogen synthase kinase-3 beta; GSK-3 beta; 2.7.11.26; Serine/threonine-protein kinase GSK3B; 2.7.11.1; GSK3B] |
Gene, Accession # | [GSK3B], Gene ID: 2932, NCBI: NP_001139628.1, UniProt: P49841 |
Catalog # | MBS9231105 |
Price | $165, $370 |
Order / More Info | Phospho-GSK3B (Ser9) Antibody from MYBIOSOURCE INC. |
Product Specific References | Stambolic V.,et al.Biochem. J. 303:701-704 (1994). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Lau K.F.,et al.Genomics 60:121-128 (1999). Rhoads A.R.,et al.Mol. Psychiatry 4:437-442 (1999). Boyle W.J.,et al.Cell 64:573-584 (1991). |