Edit |   |
---|---|
Antigenic Specificity | POLD1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'-to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200, PubMed:24022480). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433 |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 808-1107 of human POLD1 (NP 002682.2). |
Other Names | [CDC2; MDPL; POLD; CRCS10] |
Gene, Accession # | [POLD1], Gene ID: 5424, NCBI: NP_001243778.1, UniProt: P28340 |
Catalog # | MBS8545502 |
Price | $280 |
Order / More Info | POLD1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |