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Antigenic Specificity | BSG |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily (1). Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed (2). Multiple functions have been ascribed to Basigin; foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression (2-4). Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy (5, 6). A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process o |
Immunogen | Immunogen: Recombinant protein of human BSG Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [5F7; CD147; EMMPRIN; M6; OK; TCSF] |
Gene, Accession # | [BSG], Gene ID: 682, NCBI: NP_001309172.1, UniProt: P35613 |
Catalog # | MBS8504979 |
Price | $310 |
Order / More Info | BSG Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Biswas, C. et al. (1995) Cancer Res 55, 434-9. 2. Liao, C.G. et al. (2011) Mol Cell Biol 31, 2591-604. 3. Sweeny, L. et al. (2012) Exp Cell Res 318, 1788-98. 4. Lescaille, G. et al. (2012) BMC Cancer 12, 115. 5. Piao, S. et al. (2012) J Cancer Res ClinOncol 138, 627-35. 6. Bi, X.C. et al. (2011) Clin Invest Med 34, E358. 7. Wu, J. et al. (2011) Oncogene 30, 4410-27. 8. Solstad, T. et al. (2011) Blood 118, 5141-51. 9. Crosnier, C. et al. (2011) Nature 480, 534-7. |