Edit |   |
---|---|
Antigenic Specificity | Calreticulin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunofluorescence (IF), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA |
Immunogen | Immunogen: Synthetic peptide corresponding to aa(E-E-E-D-V-P-G-Q-A-K-D-E-L-C)of human Calreticulin, conjugated to KLH. |
Other Names | [RO; CRT; SSA; cC1qR; FLJ26680], [CALR; CALR; RO; CRT; SSA; cC1qR; HEL-S-99n; CRTC; ERp60] |
Gene, Accession # | [CALR], Gene ID: 811, NCBI: NP_004334.1, UniProt: P27797 |
Catalog # | MBS850229 |
Price | $280 |
Order / More Info | Calreticulin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |