JAM-A, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | JAM-A, Human |
| Clone | M.Ab.F11 |
| Host Species | Mouse |
| Reactive Species | n/a |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Yes: Immunohistochemistry - Paraffin (IHC-P), Immunofluorescence (IF), Flow Cytometry (FC), Functional Studies (FS), Immunoassay (IA), Immunoprecipitation (IP), Western Blot (WB); Not Determined: Immunohistochemistry - Frozen (IHC-F). |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) or JAM-1. JAM-A is a surface glycoprotein duplex (32 and 35 kDa) belongingto the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interactions. It co-distributes with other tight junction components such as ZO-1, 7H6 antigen, cingulin and occludin. Moreover |
| Immunogen | Immunogen: Human platelet membranes. |
| Other Names | [Junction Adhesion Molecule, JAM-1, platelet F11 receptor, F11R, platelet adhesion molecule, CD321], [F11R; F11R; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; JAM1; JCAM; UNQ264/PRO301; JAM-A; JAM-1; PAM-1] |
| Gene, Accession # | [JAM-A], Gene ID: 50848, NCBI: Q9Y624.1 |
| Catalog # | MBS584196 |
| Price | $665 |
| Order / More Info | JAM-A, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kornecki, E et al; Activation of human platelets by a stimulatory monoclonal antibody. J Biol Chem 1990, 265: 10042 2. Naik, U et al; Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. Biochem J 1995, 310: 155 3. Wang, F et al; Stimulatory antibody-induced activation and selective translocation of protein kinase C isoenzymes in human platelets. Biochem J 1995, 311: 401 4. Sobocka, M et al; Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood 2000, 95: 2600 5. Babinska, A et al; Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion. Thromb Haemost 2002, 87: 712 6. Babinska, A et al; The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques. Thromb Haemost 2007, 97: 272 7. Cavusoglu, E et al; Association of plasma levels of F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) with human atherosclerosis. JACC 2007, 50: 1768 8. Koenen, R et al; Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood 2009, 113: 4799 |
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