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Antigenic Specificity | DOK3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: DOK3 antibody detects endogenous levels of DOK3. Description: Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP. May modulate Abl function. On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP. 4 isoforms of the human protein are produced by alternative splicing.Function: DOK proteins are enzymatically inert adaptor or scaffolding prote |
Immunogen | Immunogen: A synthesized peptide derived from human DOK3 Subcellular Location: Cytoplasm. Cell Membrane. Tissue Specificity: Expressed in spleen. Predicted Cross Reactivity: Pig, Rabbit, Dog Similarity: Pig (100%), Rabbit (100%), Dog (100%) |
Other Names | [Docking protein 3; DOK 3; DOK Like Protein; Dok3; DOK3_HUMAN; DOKL Pending; Downstream of tyrosine kinase 3; p62 DOK Like Protein] |
Gene, Accession # | [DOK3], Gene ID: 79930, NCBI: NP_001138347.1, UniProt: Q7L591 |
Catalog # | MBS9600449 |
Price | $240, $280 |
Order / More Info | DOK3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |