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Antigenic Specificity | TLR1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated ac |
Immunogen | Immunogen: Recombinant protein of human TLR1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [TLR1; CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; TIL; rsc786] |
Gene, Accession # | [TLR1], Gene ID: 7096, NCBI: NP_003254.2, UniProt: Q15399 |
Catalog # | MBS8502796 |
Price | $310 |
Order / More Info | TLR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Akira, S. (2003) J Biol Chem 278, 38105-8. 2. Beutler, B. (2004) Nature 430, 257-63. 3. Dunne, A. and O'Neill, L.A. (2003) Sci STKE 2003, re3. 4. Muzio, M. et al. (2000) J Leukoc Biol 67, 450-6. 5. Ochoa, M.T. et al. (2003) Immunology 108, 10-5. 6. Takeuchi, O. et al. (2002) J Immunol 169, 10-4. 7. Sandor, F. et al. (2003) J Cell Biol 162, 1099-110. 8. Takeuchi, O. et al. (1999) Gene 231, 59-65. |