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Antigenic Specificity | CD6 |
Clone | [SPV-L14] |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular -scavenger receptor cysteine-rich- (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease. |
Immunogen | Immunogen: CD8+ cytotoxic T-cell clone |
Other Names | [T12; TP120], [CD6; CD6; TP120] |
Gene, Accession # | [CD6], Gene ID: 923, NCBI: NP_001241679.1, UniProt: P30203 |
Catalog # | MBS438533 |
Price | $190, $340, $340 |
Order / More Info | CD6 Antibody from MYBIOSOURCE INC. |
Product Specific References | Kamoun et al., J. Immunol. 127, 987, 1981 Reinherz et al., Proc. Nat. Acad. Sci. 79, 6047, 1982 Yssel, H., de Vries, J.E., Borst, J. and Spits, H. Distribution and functional analysis of a 120-130 kDa T cell surface antigen. Cell. Immunol. 105: 161-173, 1987. Bazil, V et. al. 1989. Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102. Folia. Biol. 35:289-297 |