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Antigenic Specificity | Nibrin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Nibrin antibody detects endogenous levels of Nibrin. Description: NBS1 is a member of the MRE11/RAD50 double-strand break repair complex. Involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutation results in the Nijmegen breakage syndrome (NBS), an autosomal recessive chromosomal instability syndrome.Function: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and dou |
Immunogen | Immunogen: A synthesized peptide derived from human Nibrin Subcellular Location: Nucleus. Nucleus, PML Body. Chromosome, Telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents. Tissue Specificity: Ubiquitous. Expressed at high levels in testis. |
Other Names | [AT V1; AT V2; ATV; Cell cycle regulatory protein p95; FLJ10155; MGC87362; Nbn; NBN_HUMAN; NBS 1; NBS; NBS1; Nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome; Nijmegen breakage syndrome protein 1; p95; p95 protein of the MRE11/RAD50 complex] |
Gene, Accession # | [NBN], Gene ID: 4683, NCBI: NP_001019859.1, UniProt: O60934 |
Catalog # | MBS9600578 |
Price | $240, $280 |
Order / More Info | Nibrin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |