Phospho-HSPB1-S82 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-HSPB1-S82 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small HSPs, HSP27 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the HSP27 expression increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway (2, 3). Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polyme |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S82 of human HSPB1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; DKFZp586P1322] |
| Gene, Accession # | [HSPB1-S82], Gene ID: 3315, NCBI: NP_001531.1, UniProt: P04792 |
| Catalog # | MBS8527427 |
| Price | $310 |
| Order / More Info | Phospho-HSPB1-S82 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Arrigo, A.P. and Landry, J. (1994) Cold Spring Harbor Laboratory Press, NY, 335-373. 2. Landry, J. et al. (1992) J. Biol. Chem. 267, 794-803. 3. Rouse, J. et al. (1994) Cell 78, 1027-1037. 4. Rogalla, T. et al. (1999) J. Biol. Chem. 274, 18947-18956. 5. Lavoie, J. et al. (1993) J. Biol. Chem. 268, 24210-24214. 6. Rousseau, S. et al. (1997) Oncogene 15, 2169-2177. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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