Phospho-RAF1 (S259) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-RAF1 (S259) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Dot Blot (DB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Phospho-RAF1-S259 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S259 of human RAF1. Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. |
| Immunogen | n/a |
| Other Names | [RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1; RAF1; RAF] |
| Gene, Accession # | [RAF1], Gene ID: 5894, NCBI: NP_002871.1, UniProt: P04049 |
| Catalog # | MBS9201696 |
| Price | $165, $370 |
| Order / More Info | Phospho-RAF1 (S259) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Dasgupta, P., et al., Mol. Cell. Biol. 24(21):9527-9541 (2004). Ku, N.O., et al., J. Cell Biol. 166(4):479-485 (2004). Gohlke, H., et al., Proteins 56(2):322-337 (2004). Akula, S.M., et al., Oncogene 23(30):5227-5241 (2004). Goetz, C.A., et al., J. Immunol. 172(8):4770-4778 (2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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