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Antigenic Specificity | APOE |
Clone | [1H4] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Tissue specificity: Occurs in all lipoprotein fractions |
Immunogen | Immunogen: Purified recombinant fragment of human ApoE expressed in E. Coli. |
Other Names | [AD2; LPG; LDLCQ5; MGC1571] |
Gene, Accession # | [APOE], Gene ID: 348, NCBI: NP_000032.1, UniProt: P02649 |
Catalog # | MBS8538784 |
Price | $280 |
Order / More Info | APOE Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |