Human CD42b (gpIb) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human CD42b (gpIb) |
| Clone | [RKCD42] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.5 mg, 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD42b (gpIb) is part of a Glycoprotein Ib-IX-V (GPIb- IX-V) complex, the receptor for von Willebrand factor (VWF). This receptor plays a critical role in thrombus formation in damaged blood vessels under high shear. ssociation between VWF and GPIb-IX-V allows the adhesion protein to tether (or capture) rapidly flowing platelets into the developing thrombus. A fast off-rate of dissociation, however, means that platelets rapidly detach from VWF, unless integrins such as IIb3 or 21 are activated by intracellular signals, thereby enabling them to bind their ligands and mediate stable adhesion and thrombus growth. |
| Immunogen | Host Note: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant E. coli-derived Human CD42b. |
| Other Names | [Mouse Human CD42b; cd42; cd-42;; mab; gpibB], [GP1BA; GP-Ib alpha; GPIb-alpha; GPIbA] |
| Gene, Accession # | [CD42], Gene ID: 2811, NCBI: P07359.1, UniProt: P07359 |
| Catalog # | MBS550103 |
| Price | $480, $775 |
| Order / More Info | Human CD42b (gpIb) Antibody from MYBIOSOURCE INC. |
| Product Specific References | • biclonal (cd34 CD42b ) myeloblastic and megakaryoblastic transformation of chronic myeloproliferative/myelodysplastic disorders.Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 5242. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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