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Antigenic Specificity | TERT |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: TERT antibody detects endogenous levels of total TERT. Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and rel |
Immunogen | Immunogen: A synthetic peptide of human TERT Subcellular Location: Nucleus > Nucleolus. Nucleus > Nucleoplasm. Nucleus. Chromosome > Telomere. Cytoplasm. Nucleus > PML Body. Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphor |
Other Names | [CMM9; DKCA2; DKCB4; EST2; HEST2; htert; hTRT; PFBMFT1; TCS1; Telomerase associated protein 2; Telomerase catalytic subunit; Telomerase reverse transcriptase; Telomerase-associated protein 2; Telomere Reverse Transcriptase; TERT; TERT_HUMAN; TP2; TRT] |
Gene, Accession # | [TERT], Gene ID: 7015, NCBI: NP_001180305.1, UniProt: O14746 |
Catalog # | MBS9607780 |
Price | $240, $280 |
Order / More Info | TERT Antibody from MYBIOSOURCE INC. |
Product Specific References | Bai C, Liu X, Xu J, Qiu C, Wang R, Zheng J; Journal: Hum Pathol. Expression profiles of stemness genes in gastrointestinal stromal tumor. Zhang Y, Chen Z, Wang T, Yang J, Li R, Wang S, Liu J, Ye Z; Journal: Oncotarget. Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. |