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Antigenic Specificity | SOD1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total SOD1 protein. SOD1, Cu/Zn superoxide dismutase, is a major antioxidant enzyme that catalyzes the conversion of superoxide anion to hydrogen peroxide and molecular oxygen (1). SOD1 is ubiquitously expressed and is localized in the cytosol, nucleus and mitochondrial intermembrane space. The SOD1 gene locus is on chromosome 21 in a region affected in Down Syndrome (2). In addition, over 100 distinct SOD1 inherited mutations have been identified in the familial form of amyotrophic lateral sclerosis (ALS), a progressive degenerative disease of motor neurons (3-5). Despite the fact that SOD1 helps to eliminate toxic reactive species, its mutations in ALS have been described as gain-of-function (5). T |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human SOD1. |
Other Names | [SOD1; ALS; ALS1; IPOA; SOD] |
Gene, Accession # | [SOD1], Gene ID: 6647, NCBI: NP_000445.1, UniProt: P00441 |
Catalog # | MBS9413825 |
Price | $255 |
Order / More Info | SOD1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |