Beta-Catenin, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Beta-Catenin, Human |
| Clone | 9F2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: Beta-catenin belongs together with alpha- and gamma-catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Beta-catenin is highly homologous to gamma-catenin (plakoglobin) although its function differs from that of plakoglobin. Whereas plakoglobin has been found to suppress tumorigenicity, beta-catenin potentiates hyperproliferation and tumor formation. In the nucleus beta-catenin it complexes with transcription factors and thus regulates the expression of specific genes. By its dual role, i.e. a structural role in cell-cell junctions and a regulatory role in the nucleus, beta-catenin can transduce changes in cell adhesion and junction formation to control transmembrane signal |
| Immunogen | n/a |
| Other Names | [beta-catenin; beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa], [ctnnb1; ctnnb; beta-catenin] |
| Gene, Accession # | Gene ID: 549712, NCBI: NP_001016958.1 |
| Catalog # | MBS584387 |
| Price | $520 |
| Order / More Info | Beta-Catenin, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Johnson, K et al; P- and E-cadherins are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207: 252 2. Sacco, P et al; Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem 1995, 270: 20201 3. Hakuno, M et al; Dissociation of intra- and extracellular domains of desmosomal cadherins and E-cadherin in Hailey-Hailey disease and Darier's disease. Br J Dermatol 2000, 142: 702 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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