BRCC3 (N-Term) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | BRCC3 (N-Term) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This BRCC3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-50 amino acids from human BRCC3. Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC |
| Immunogen | n/a |
| Other Names | [Purified Rabbit (Pab); Lys-63-specific deubiquitinase BRCC36; 3419-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36; BRCC3; BRCC36; C61A; CXorf53] |
| Gene, Accession # | [BRCC3], Gene ID: 79184, NCBI: NP_001018065.1, UniProt: P46736 |
| Catalog # | MBS9216570 |
| Price | $165, $370 |
| Order / More Info | BRCC3 (N-Term) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Kenwrick S.,et al.Hum. Mol. Genet. 1:179-186(1992).Fisch P.,et al.Oncogene 8:3271-3276(1993).Dong Y.,et al.Mol. Cell 12:1087-1099(2003).Ota T.,et al.Nat. Genet. 36:40-45(2004).Ross M.T.,et al.Nature 434:325-337(2005). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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