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Antigenic Specificity | HIRA (Center), 431-461 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: chicken, mouse, Xenopus) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-461 amino acids from the Central region of human HIRA. HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embr |
Immunogen | n/a |
Other Names | [Protein HIRA; TUP1-like enhancer of split protein 1; HIRA; DGCR1; HIR; TUPLE1] |
Gene, Accession # | [HIRA], Gene ID: 7290, NCBI: NP_003316.3, UniProt: P54198 |
Catalog # | MBS9214151 |
Price | $165, $370 |
Order / More Info | HIRA (Center), 431-461 Antibody from MYBIOSOURCE INC. |
Product Specific References | Zhang,R., Mol. Cell. Biol. 27 (6), 2343-2358 (2007) Tang,Y., Nat. Struct. Mol. Biol. 13 (10), 921-929 (2006) |