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Antigenic Specificity | Mouse CD278 |
Clone | [C398.4A] |
Host Species | Hamster |
Reactive Species | human, porcine, rat |
Isotype | IgG |
Format | unconjugated |
Size | 0.25 mg |
Concentration | IgG concentration 0.5mg/ml |
Applications | Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This item recognises CD278, also known as Inducible T cell costimulator or ICOS, a CD28-superfamily costimulatory molecule. It is expressed on activated T cells and resting memory T cells. It enhances all the basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines and up-regulation of molecules that mediate cell-cell interaction. It is essential for the efficient interaction between B and T cells and is involved in antibody responses to T cell dependent antigens. It up-regulates the synthesis of interleukin-10, but not interleukin-2 and prevents the apoptosis of pre-activated T cells. Clone C398.4A has been reported to costimulate T cell activation and proliferation in vitro. MBS219570 recognises CD278, a |
Immunogen | Immunogen: Mouse T cell clone D10.G4.1 Buffer Solution: Phosphate buffered saline Target Species: Mouse |
Other Names | [inducible T-cell costimulator; Inducible T-cell costimulator; inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; inducible costimulator; inducible T-cell co-stimulator; Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278], [ICOS; ICOS; AILIM; CD278; CVID1; AILIM] |
Gene, Accession # | [CD278], Gene ID: 29851, NCBI: NP_036224.1 |
Catalog # | MBS219570 |
Price | $430 |
Order / More Info | Mouse CD278 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |