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Antigenic Specificity | GILT, Mouse |
Clone | MaP.mGILT6 |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Ctometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Antibodies derived from clone MaP.mGILT6 recognize mouse gamma-interferon-inducible lysosomal thiol reductase (GILT). GILT facilitates major histocompatibility complex (MHC) class II-restricted processing through reduction of protein disulfide bonds in the endocytic pathway. GILT can also facilitate the transfer of disulfide-containing antigens into the cytosol, enhancing their cross-presentation by MHC class I. Human GILT consists of 261 amino acids with a 37 amino acid signal sequence and a 224 amino acid precursor form. In general, the 35 kDa precursor is tagged with mannose-6- phosphate (M6P) residues and transported to the endocytic pathway via the M6P receptor (M6PR). A small fraction of the precursor is secreted as a disulfide-linked |
Immunogen | Immunogen: Insect-cell expressed recombinant mouse GILT |
Other Names | n/a |
Gene, Accession # | [GILT] |
Catalog # | MBS584662 |
Price | $420 |
Order / More Info | GILT, Mouse Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |