SMURF2 (N-term), 6-36 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SMURF2 (N-term), 6-36 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse (predicted reactivity: zebrafish) |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 2 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This SMURF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human SMURF2. SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83% identical to SMURF1, codes for a C2-WW-HECT domain ubiquitin ligase that associates constitutively with SMAD7. Binding to SMAD7 induces export of SMURF2 and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it causes receptor and SMAD7 degradation. A strong interaction of second and third SMURF2 WW domains has been identified with SMAD1, SMAD2, and SMAD3, but not SMAD4. Western blot analysis showed that SMURF2 selectively downregulates the transcription of SMAD2 and SMAD1, but not SMAD3. |
| Immunogen | n/a |
| Other Names | [E3 ubiquitin-protein ligase SMURF2; hSMURF2; 632-; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2] |
| Gene, Accession # | [SMURF2], Gene ID: 64750, NCBI: NP_073576.1, UniProt: Q9HAU4 |
| Catalog # | MBS9207187 |
| Price | $165, $370 |
| Order / More Info | SMURF2 (N-term), 6-36 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Zhang, Y., et al., Proc. Natl. Acad. Sci. U.S.A. 98(3):974-979 (2001). Kavsak, P., et al., Mol. Cell 6(6):1365-1375 (2000). Lin, X., et al., J. Biol. Chem. 275(47):36818-36822 (2000). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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