Rev-erbalpha Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Rev-erbalpha |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Reverse orientation c-erbA gene alpha (Rev-erbalpha, EAR-1, or NR1D1) is a widely expressed member of the orphan nuclear receptor family of proteins (1). Rev-erbalpha is highly expressed in adipose tissue, skeletal muscle, brain and liver, and regulates cellular proliferation and differentiation. Expression increases during differentiation in adipocytes and ectopic expression of Rev-erbalpha potentiates the adipocyte differentiation of 3T3-L1 cells (2). In addition, expression oscillates with circadian rhythm in liver cells and Rev-erbalpha regulates expression of BMAL1, ApoA-I and ApoC-III, all key regulators of circadian rhythm (3, 4, 5, 6, 7). Phosphorylation of Rev-erbalpha Ser55 and Ser59 by GSK3beta appears to stabilize Rev-erbalpha p |
| Immunogen | Immunogen: Fusion protein of human NR1D1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [NR1D1; EAR1; THRA1; THRAL; ear-1] |
| Gene, Accession # | [hRev], Gene ID: 9572, NCBI: NP_068370.1, UniProt: P20393 |
| Catalog # | MBS8505628 |
| Price | $310 |
| Order / More Info | Rev-erbalpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Harding, H.P. and Lazar, M.A. (1993) Mol. Cell Biol. 13, 3113-3121. 2. Chawla, A. and Lazar, M.A. (1993) J. Biol. Chem. 268, 16265-16269. 3. Torra, I.P. et al. (2000) Endocrinology 141, 3799-3806. 4. Preitner, N. et al. (2002) Cell 110, 251-260. 5. Vu-Dac, N. et al. (1998) J. Biol.Chem. 273, 25713-25720. 6. Coste, H. and Rodriguez, J.C. (2002) J. Biol. Chem. 277, 27120-27129. 7. Raspe, E. et al. (2002) J. Lipid Res. 43, 2172-2179. 8. Yin, L. et al. (2006) Science 311, 1002-1005. 9. Migita, H. et al. (2004) FEBS Lett. 561, 69-74. 10. Yin, L. and Lazar, M.A. (2005) Mol. Endocrinol. 19, 1452-1459. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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