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Antigenic Specificity | Rabbit SirT1 (Ab-47) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: SirT1 (Ab-47) detects endogenous levels of total SirT1. This gene encodes a member of the sirtuin family ofproteins, homologs to the yeast Sir2 protein. Members of thesirtuin family are characterized by a sirtuin core domain andgrouped into four classes. The functions of human sirtuinshave not yet been determined; however, yeast sirtuinproteins are known to regulate epigenetic gene silencingand suppress recombination of rDNA. |
Immunogen | Immunogen: A synthesized peptide derived from human SirT1.. Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mMNaCl, 0.02% sodium azide and 50% glycerol.. Subcellular location: Cytoplasm. Mitochondrion and Nucleus, PML body.Cytoplasm. Nucleus. Recruited to the nuclear bodies via itsinteraction with PML (PubMed:12006491). Colocalized withAPEX1 in the nucleus (PubMed:19934257). May be found innucleolus, nuclear euchromatin, heterochromatin and innermembrane (PubMed:15469825). |
Other Names | [NAD-dependent protein deacetylase sirtuin-1 isoform b; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1; sirtuin 1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1], [SIRT1; SIRT1; SIR2L1; SIR2L1; hSIRT1; hSIR2; 75SirT1] |
Gene, Accession # | [SirT1], Gene ID: 23411, NCBI: NP_001135970.1, UniProt: Q96EB6 |
Catalog # | MBS004131 |
Price | $440, $715 |
Order / More Info | Rabbit SirT1 (Ab-47) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |