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Antigenic Specificity | RIPK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | RIPK1 Antibody: RIPK1 (Receptor Interacting Protein) is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell's decision to live or die. RIPK1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIPK1 is important for signallling to NFκ-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIPK1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-κB activation. RIPK1-deficient mice fail to thrive, displaying extensive apopt |
Immunogen | Immunogen: RIPK1 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human RIPK1. Buffer: RIPK1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [RIPK1; RIP; RIP1; RIP; Cell death protein RIP; RIP-1; receptor (TNFRSF)-interacting serine-threonine kinase 1], [RIPK1; RIPK1; RIP; RIP1; RIP; RIP1; RIP-1] |
Gene, Accession # | [RIPK1], Gene ID: 8737, NCBI: NP_003795, UniProt: Q13546 |
Catalog # | MBS150077 |
Price | $375 |
Order / More Info | RIPK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |