PSEN1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PSEN1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: PSEN1 antibody detects endogenous levels of total PSEN1. Description: Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated gamma-secretase activity for amyloid-beta protein processing (1, 2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2, 3).Function: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and |
| Immunogen | Immunogen: A synthesized peptide derived from human PSEN1 Subcellular Location: Endoplasmic Reticulum Membrane. Golgi Apparatus Membrane. Cell Surface. Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils. Tissue Specificity: Detected in azurophile granules in neutrophils and in platelet cytoplasmic granules ( |
| Other Names | [AD3; Ad3h; FAD; Homo Sapiens Clone CC44 Senilin 1; Presenilin-1 CTF12; Protein S182; PS 1; PS-1; PS1-CTF12; PSEN1; PSN1_HUMAN; PSNL1; S182] |
| Gene, Accession # | [PSEN1], Gene ID: 5663, NCBI: NP_000012.1, UniProt: P49768 |
| Catalog # | MBS9607563 |
| Price | $240, $280 |
| Order / More Info | PSEN1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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