Edit |   |
Antigenic Specificity | ApoE |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to human ApoE. Apolipoprotein-E (apoE) is a protein component of plasma lipoproteins. Three common ApoE alleles have been identified: ApoE2, ApoE3, and ApoE4. The corresponding three major isoforms, E2, E3, and E4, are recognized according to their relative position after isoelectric focusing. ApoE mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (Apo B/E) receptor and for the specific Apo-E receptor (chylomicron remnant) of hepatic tissues. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased p |
Immunogen | n/a |
Other Names | [apolipoprotein E isoform b; Apolipoprotein E; apolipoprotein E; apolipoprotein E], [APOE; APOE; AD2; LPG; APO-E; ApoE4; LDLCQ5; Apo-E] |
Gene, Accession # | [ApoE], Gene ID: 348, NCBI: NP_000032.1, UniProt: P02649 |
Catalog # | MBS856752 |
Price | $280 |
Order / More Info | ApoE Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Team Genome Res. 14:2121-2127(2004). 2. Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site.Shuvaev V.V., Fujii J., Kawasaki Y., Itoh H., Hamaoka R., Barbier A., Ziegler O., Siest G., Taniguchi N.Biochim. Biophys. Acta 1454:296-308(1999). |