APEX1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | APEX1 |
| Clone | [1518CT337.123.86.269.232] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This APEX1 antibody is generated from a mouse immunized with a recombinant protein of human APEX1. Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, |
| Immunogen | n/a |
| Other Names | [Purified Mouse (Mab); DNA-(apurinic or apyrimidinic site) lyase, 31--; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1; DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; APEX1; APE; APE1; APEX; APX; HAP1; REF1] |
| Gene, Accession # | [APEX1], Gene ID: 328, NCBI: NP_001231178.1, UniProt: P27695 |
| Catalog # | MBS9215407 |
| Price | $165, $370 |
| Order / More Info | APEX1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Robson C.N.,et al.Nucleic Acids Res. 19:5519-5523(1991).Demple B.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:11450-11454(1991).Seki S.,et al.Biochim. Biophys. Acta 1131:287-299(1992).Xanthoudakis S.,et al.EMBO J. 11:3323-3335(1992).Cheng X.B.,et al.Nucleic Acids Res. 20:370-370(1992). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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