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Antigenic Specificity | Presenilin 1, |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, primate, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2). Presenilins form the catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Evidence suggests cleavage of APP by gamma-secretase and the production of Abeta (42 aa) is likely to play a important or casual role in the development of Alzheimer's disease. |
Immunogen | Immunogen: Peptide corresponding to residues around valine 293 of human presenilin 1 |
Other Names | [Presenilin-1; Presenilin-1; presenilin-1; presenilin 1; Protein S182], [PSEN1; PSEN1; AD3; FAD; PS1; PS-1; S182; AD3; PS1; PSNL1; PS-1; PS1-CTF12] |
Gene, Accession # | Gene ID: 5663, NCBI: P49768.1 |
Catalog # | MBS555285 |
Price | $450 |
Order / More Info | Presenilin 1, Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |