Human CRMP-2 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Human CRMP-2 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Human CRMP-2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Collapsin Response Mediator Protein-2 (CRMP-2) is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3beta inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3beta (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is fo |
| Immunogen | Immunogen: A fusion protein of human CRMP-2 |
| Other Names | [CRMP-2 Rabbit pab], [DPYSL2; CRMP2; DHPRP2; DRP-2; DRP2] |
| Gene, Accession # | [CRMP-2], Gene ID: 1808, NCBI: NP_001184222.1, UniProt: Q16555 |
| Catalog # | MBS125738 |
| Price | $275, $430 |
| Order / More Info | Human CRMP-2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Gu, Y. and Ihara, Y. (2000) J Biol Chem 275, 17917-20.2. Yoshimura, T. et al. (2005) Cell 120, 137-49.3. Fukata, Y. et al. (2002) Nat Cell Biol 4, 583-91.4. Goshima, Y. et al. (1995) Nature 376, 509-14.5. Cole, A.R. et al. (2004) J Biol Chem 279, 50176-80. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies