SFPQ (578) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificitySFPQ (578)
Clonemonoclonal
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG
Formatunconjugated
Size0.02 mL, 0.05 mL, 0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
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DescriptionDNA and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in a spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatory elements which represses exon inclusion.
ImmunogenHost Note: This monoclonal antibody is produced by immunizing mice with a polypeptide corresponding to SFPQ protein.
Other Names[PPP1R140, PSF], [SFPQ; SFPQ; PSF; POMP100; PPP1R140; PSF; PSF1
Gene, Accession #[SFPQ], Gene ID: 6421, NCBI: NP_005057.1, UniProt: P23246
Catalog #MBS435103
Price$225, $350, $565
Order / More InfoSFPQ (578) Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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