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Antigenic Specificity | sRANK Ligand |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The receptor activator of NF-kB ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T cell-dependent immune response, lymph node organogenesis and bone formation. RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor. Activation of T cells, such as by treatment with interleukin-7, induces RANK-L production and leads to an increase of osteoclast formation and bone loss. Finally, sRANK-L can activate the antiapoptotic kinase Akt through a signaling complex involving Src kinase and TRAF6, suggesting sRANK-L may also play a role in regulating apoptosis. This antibody will recognize both the soluble form and the u |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 14 amino acid peptide from near the center of human sRANK-L. |
Other Names | [sRANK-L, TNFSF11, TRANCE, OPGL] |
Gene, Accession # | [sRANK], Gene ID: 8600, NCBI: NP_003692 |
Catalog # | MBS9406056 |
Price | $320 |
Order / More Info | sRANK Ligand Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |