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Antigenic Specificity | ROCK2 (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This ROCK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1346-1380 amino acids from the C-terminal region of human ROCK2. Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic dif |
Immunogen | n/a |
Other Names | [Rho-associated protein kinase 2; Rho kinase 2; Rho-associated; coiled-coil-containing protein kinase 2; Rho-associated; coiled-coil-containing protein kinase II; ROCK-II; p164 ROCK-2; ROCK2; KIAA0619] |
Gene, Accession # | [ROCK2], Gene ID: 9475, NCBI: NP_004841.2, UniProt: O75116 |
Catalog # | MBS9206549 |
Price | $165, $370 |
Order / More Info | ROCK2 (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Takahashi N.,et al.Genomics 55:235-237(1999). Ishikawa K.,et al.DNA Res. 5:169-176(1998). Hillier L.W.,et al.Nature 434:724-731(2005). Kawano Y.,et al.J. Cell Biol. 147:1023-1038(1999). Sebbagh M.,et al.J. Exp. Med. 201:465-471(2005). |