Granzyme B (NK/T-Cell Lymphoma Marker) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Granzyme B (NK/T-Cell Lymphoma Marker) |
| Clone | [GZMB/2403] |
| Host Species | Mouse |
| Reactive Species | human. |
| Isotype | IgG2b |
| Format | unconjugated |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) Formalin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkins Diseas |
| Immunogen | Immunogen: Recombinant fragment of human GZMB protein (around aa 73-187) Cellular Localization: Cytoplasmic |
| Other Names | [Cathepsin G-like 1; CCPI; CGL1; CSPB; CTLA-1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; Granzyme B; Granzyme-2; GRB; Gzmb; Human lymphocyte protein (Hlp); Lymphocyte protease; SECT; T-cell serine protease 1-3E] |
| Gene, Accession # | [GZMB], Gene ID: 3002, NCBI: NP_004122.2, UniProt: P10144 |
| Catalog # | MBS4380448 |
| Price | $190, $340, $340 |
| Order / More Info | Granzyme B (NK/T-Cell Lymphoma Marker) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Shresta, S., et al. 1995. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc. Natl. Acad. Sci. USA 92: 5679-5683. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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