Mouse Irf3 (N-term), 46-72 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Mouse Irf3 (N-term), 46-72 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse (predicted reactivity: bovine, porcine) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.35 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3. Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN- |
| Immunogen | n/a |
| Other Names | [Interferon regulatory factor 3; IRF-3; Irf3] |
| Gene, Accession # | [Irf3], Gene ID: 54131, NCBI: NP_058545.1, UniProt: P70671 |
| Catalog # | MBS9202338 |
| Price | $165, $370 |
| Order / More Info | Mouse Irf3 (N-term), 46-72 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Marichal, T., et al. J. Allergy Clin. Immunol. 126(4):836-844(2010) Menachery, V.D., et al. J. Virol. 84(19):9685-9694(2010) Carrigan, S.O., et al. J. Immunol. 185(6):3602-3609(2010) Wang, J., et al. J. Immunol. 185(3):1720-1729(2010) Farlik, M., et al. Immunity 33(1):25-34(2010) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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