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Antigenic Specificity | EPHA2/3/4 (Ab-588/596) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total EPHA2/3/4 protein. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized non-phosphopeptide derived from human EPHA2/3/4 around the phosphorylation site of tyrosine 588/596 (T-Y(p)-V-D-P). |
Other Names | [EC 2.7.10.1; ECK; Ephrin type-A receptor 2 precursor; Epithelial cell kinase; MPK-5] |
Gene, Accession # | [EPHA2/3/4], Gene ID: 1969, NCBI: NP_004422.2, UniProt: P29317 |
Catalog # | MBS9414320 |
Price | $200, $255 |
Order / More Info | EPHA2/3/4 (Ab-588/596) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |