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Antigenic Specificity | Human Target of rapamycin complex 2 subunit MAPKAP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'S |
Immunogen | Immunogen: Recombinant human Target of rapamycin complex 2 subunit MAPKAP1 protein (1-290aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48588 |
Other Names | [TORC2 subunit MAPKAP1; Mitogen-activated protein kinase 2-associated protein 1; Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; mSIN1; MAPKAP1; MIP1; SIN1], [MAPKAP1; MAPKAP1; MIP1; SIN1; JC310; SIN1b; SIN1g; MIP1; SIN1; TORC2 subunit MAPKAP1; SAPK-interacting protein 1; mSIN1] |
Gene, Accession # | [MAPKAP1], Gene ID: 79109, NCBI: NP_001006618.1, UniProt: Q9BPZ7 |
Catalog # | MBS1492926 |
Price | $120, $160 |
Order / More Info | Human Target of rapamycin complex 2 subunit MAPKAP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |