TNF-alpha Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | TNF-alpha |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TNF-alpha, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein (1, 2). Membrane-bound TNF-alpha is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer (2). Both membrane and soluble forms of TNF-alpha are biologically active. TNF-alpha is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophages (1). Cellular response to TNF-alpha is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological context. Activation of kinase pathways (including JNK, Erk (p44/42), p38 MAPK, and NF-kappaB) promotes the survival of cell |
| Immunogen | Immunogen: C term-peptide of human TNF Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [TNF; TNFSF2; DIF; Tumor necrosis factor; TNF a; TNF alpha] |
| Gene, Accession # | [TNF-alpha], Gene ID: 7124, NCBI: NP_000585.2, UniProt: P01375 |
| Catalog # | MBS8505826 |
| Price | $310 |
| Order / More Info | TNF-alpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Aggarwal, B.B. (2003) Nat Rev Immunol 3, 745-56. 2. Hehlgans, T. and Pfeffer, K. (2005) Immunology 115, 1-20. 3. Lin, P.L. et al. (2007) J Investig Dermatol Symp Proc 12, 22-5. 4. Brennan, F.M. and McInnes, I.B. (2008) J Clin Invest 118, 3537-45. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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