Toll Interleukin 1 receptor adaptor protein (TIRAP) (IN) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Toll Interleukin 1 receptor adaptor protein (TIRAP) (IN) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors (4,5). In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling (6). Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-κB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling (6,7) |
| Immunogen | Immunogen: Rabbit polyclonal TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP. |
| Other Names | [MyD88 adapter-like protein; Adaptor protein Wyatt], [Tirap; Tirap; Mal; Wyatt; Tlr4ap; AA407980; C130027E04Rik; Mal; TIR domain-containing adapter protein] |
| Gene, Accession # | [TIRAP], Gene ID: 117149, NCBI: NP_473437.2, UniProt: Q99JY1 |
| Catalog # | MBS395622 |
| Price | $510 |
| Order / More Info | Toll Interleukin 1 receptor adaptor protein (TIRAP) (IN) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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